Overview
- Researchers used whole‑body MRI with AI to quantify muscle, visceral fat and subcutaneous fat, and to estimate each participant’s brain age from structural brain scans.
- Higher visceral‑fat‑to‑muscle ratios correlated with older brain‑age estimates, while fat under the skin showed no significant association with brain age.
- The cohort included 1,164 healthy adults from four sites with a mean age of about 55, providing multi‑site data for the analysis.
- The results are being presented at the RSNA meeting in Chicago and are considered preliminary until peer‑reviewed, with investigators describing the work as ongoing and observational.
- Authors propose targeting visceral fat reduction while preserving muscle as an actionable goal and suggest the biomarkers could inform design and dosing of GLP‑1 weight‑loss therapies.