Particle.news

Download on the App Store

Routine Blood Test Flags Early Alzheimer’s Decline Risk

Matching TyG index readings with brain imaging markers could enable earlier intervention in high-risk Alzheimer’s cases.

image: ©NataliaDeriabina iStock
Image
Image

Overview

  • Patients with the highest triglyceride-glucose (TyG) scores experienced cognitive decline four times faster over three years than those with lower insulin resistance readings.
  • Presented at the European Academy of Neurology Congress 2025, the University of Brescia study tracked 315 non-diabetic individuals with cognitive deficits, 200 of whom had biologically confirmed Alzheimer’s disease.
  • High TyG levels were linked to blood-brain barrier disruption and cardiovascular risk factors but showed no association with the APOE ε4 genotype.
  • As a low-cost, widely available marker, the TyG index could refine selection for anti-amyloid and anti-tau trials and prompt timely lifestyle or pharmacological interventions.
  • Researchers are now assessing whether TyG index readings correspond with neuroimaging biomarkers to improve early detection and patient stratification.