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Rosie O’Donnell Says She’s Shocked to Fit Size 12, Calls Mounjaro ‘Life Saver’

Her social-media update highlights how the FDA-approved diabetes drug Mounjaro has driven her recent weight loss.

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Rosie O'Donnell attends the "Burlesque: The Musical" World Premiere at The Savoy Theatre on July 22, 2025 in London, England.
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Overview

  • O’Donnell posted an Instagram photo on Aug. 12 to reveal she now fits into size 12 clothing.
  • She credited Mounjaro for her transformation, describing the FDA-approved diabetes drug as a “life saver.”
  • The dressing-room shot was taken by friends Camryn Manheim and Robin Ruzan and sparked widespread media coverage.
  • After relocating to Ireland in January, she said cooking for herself instead of relying on a personal chef furthered her slimming.
  • Her new figure was first noticed publicly at the Burlesque: The Musical premiere in London in late July.