Overview
- The fixture kicks off at 21:10 at Estadio Único Madre de Ciudades in Santiago del Estero with live coverage on TyC Sports and streaming via TyC Sports Play.
- Marcelo Gallardo’s squad will be without forward Maximiliano Salas after he suffered a knee sprain in training.
- Mariano Campodónico takes charge of San Martín de Tucumán for the first time after the club replaced Ariel Martos following uneven league form.
- The winner will meet Unión de Santa Fe in the Round of 16 after Santa Fe defeated Rosario Central in the previous round.
- River and San Martín last met on February 24, 2019, when River won 2–1 away thanks to goals from Juan Fernando Quintero and Matías Suárez.