Overview

• Health authorities are urging expansion of low-dose CT scans to more high-risk individuals after screening rates remain in the single digits globally
• Genomic analyses in mid-2025 have linked fine particulate pollution to tobacco-like DNA mutations in tumors of never-smokers
• Targeted therapies such as EGFR inhibitors are gaining support for non-smoker patients with distinct genetic mutations driving their disease
• Clinicians highlight that persistent coughs beyond 3–8 weeks, chest pain, hemoptysis and unexplained weight loss should trigger prompt diagnostic evaluation
• Public health calls now extend beyond smoking cessation to include tighter outdoor air standards, reduced indoor cooking pollution and equitable access to early detection and treatment