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Revolutionary DNA Microbead Technique Enhances Organoid Complexity

Interdisciplinary team develops method to control tissue growth signals, offering breakthroughs in disease research and drug development.

Retinal organoid with a microscopically small bead of DNA (yellow) and various retinal cell types (green, cyan, magenta). | © Cassian Afting, AG Wittbrodt
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Overview

  • New technique uses DNA microbeads to control organoid development from within.
  • Method allows precise timing and location for the release of growth signals in tissue.
  • Successfully tested on retinal organoids of Japanese rice fish medaka.
  • Enables more realistic cell compositions and better mimicking of natural tissues.
  • Potential to advance human development research and organoid-based drug studies.