Overview

• The Advanced Science review catalogued 112 iBCI studies, nearly half of which appeared since 2020, reflecting rapid research growth.
• A first-of-its-kind global registry now tracks 80 participants implanted with iBCIs across the United States, Europe, China, and Australia.
• The analysis revealed that trials predominantly focus on device performance metrics, with only 17.9% evaluating clinical outcomes for patients.
• Participants have used implantable interfaces to control robotic prosthetic limbs and consumer digital technologies in preliminary demonstrations.
• Review authors provide concrete design guidelines to harmonize outcome measures and guide upcoming trials toward meaningful patient benefits.