Restoring NAD+ Reverses Alzheimer’s Signs in Mice, Study Finds
A peer-reviewed Cell Reports Medicine study links Alzheimer’s to severe NAD+ loss in humans, with P7C3-A20 restoring cognition in two mouse models.
Overview
- Researchers report that maintaining or restoring the brain’s NAD+ balance prevented disease onset and reversed advanced pathology in mice.
- Analysis showed a pronounced decline of NAD+ in postmortem human Alzheimer’s brains as well as in mouse models of the disease.
- The team used the pharmacological agent P7C3-A20 to restore NAD+ balance in the brain.
- Experiments covered two genetic mouse lines, one with multiple human amyloid-processing mutations and another with a human tau mutation.
- Delayed treatment in mice with advanced disease repaired major pathological changes, and both lines regained full cognitive function.