Overview

• Researchers at RMIT University and partner institutes created nano-droplet coatings from resilin-mimetic proteins that fully blocked E. coli attachment in laboratory conditions.
• The coating disrupts bacterial cell membranes via electrostatic interactions, causing leakage of cellular contents without harming human cells.
• Its mechanical mode of action offers a route to prevent antibiotic resistance associated with traditional drugs.
• Potential applications include spray-on barriers for medical implants, surgical tools, catheters and wound dressings to reduce infection rates.
• Next steps involve assessing effectiveness against additional bacterial strains and confirming long-term stability and scalability for clinical use.