Overview

• A Josep‑Carreras Institute team led by Manel Esteller reports in Cell Reports Medicine a minimally invasive multi‑omics portrait integrating genomics, proteomics, metabolomics, epigenomics and microbiomics.
• Samples taken about a year before Maria Branyas Morera’s death showed protective gene variants, efficient fat and cholesterol metabolism, very low systemic inflammation and a gut microbiome rich in beneficial Bifidobacteria.
• Epigenetic clocks placed her biological age roughly 10 to 15 years below her chronological age despite visible hallmarks of aging.
• Researchers documented extremely short telomeres and note this may have limited cancer risk in her case, alongside immune aging features including clonal hematopoiesis and shifts in B‑cell populations.
• The authors present the results as hypothesis‑generating for targeting aging and informing age‑related blood cancers, stressing that conclusions from a single case are tentative and lifestyle links remain unproven.