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2h ago

Researchers Identify 0.5–1.6 Acoustic Dose Window for Ultrasound Blood–Brain Barrier Opening

The Device paper establishes a measurable target to standardize procedures for drug delivery in glioblastoma.

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Overview

  • Researchers from Mass General Brigham and the University of Maryland analyzed 972 sonications across 58 treatments in 23 high-grade glioma patients.
  • Acoustic emission dose, derived from microbubble signals, predicted the degree of barrier opening and guided real-time ultrasound power adjustments.
  • The defined therapeutic window of 0.5 to 1.6 AED reliably produced localized blood–brain barrier disruption intended to facilitate targeted drug delivery.
  • The publication focuses on dosimetry and spatial control, with safety outcomes and treatment effectiveness to be reported in separate analyses.
  • The study appears in Device (DOI: 10.1016/j.device.2025.100894) with disclosed support from InSightec, the Focused Ultrasound Foundation, NIH, and the American Cancer Society.