Research Uncovers Key Mechanisms in Cancer Cell Migration

New study reveals how cellular contractility influences tumor spread and metastasis risk.

Researchers identify two distinct contractility modes in cancer cells: one that maintains cluster integrity and another that facilitates invasion.
The balance between cellular forces on each other and the extracellular matrix dictates the likelihood of cancer cell detachment and spread.
Findings suggest that changes in actin cytoskeleton structure underpin differences in invasive potential among cancer cells.
Patient-derived tumor explants show a decrease in cohesive cellular forces during tumor progression, hinting at increased metastasis risk.
Study highlights the complex interplay of cellular mechanics as a potential target for therapeutic interventions in cancer treatment.