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Reports: Cardinals' James Conner to Undergo Ankle Surgery, Expected to Miss Season

Official confirmation is pending, with insiders calling the ankle damage severe.

Sep 21, 2025; Santa Clara, California, USA; Arizona Cardinals running back James Conner (6) avoids the tackle by. San Francisco 49ers cornerback Deommodore Lenoir (2) during the first half at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images/File Photo
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Overview

  • Conner suffered a right ankle injury in the third quarter against the 49ers, was carted off, and was ruled out for the game.
  • ESPN’s Adam Schefter reported the injury is season-ending and will require surgery, while NFL Network’s Ian Rapoport said surgery is planned with Conner out indefinitely.
  • Head coach Jonathan Gannon acknowledged the ankle injury but said postgame he did not yet know the severity, as further testing continues.
  • With Conner sidelined, Trey Benson is expected to lead the backfield, with Emari Demercado and Bam Knight in support and a likely practice-squad elevation for Michael Carter.
  • The 30-year-old back is coming off consecutive 1,000-yard seasons and is under contract through 2026, with his 2025 base salary guaranteed for injury.