Overview

• MUSAS uses a silicone-based, temperature-responsive disk patterned with compartmentalized lamellae and shape-memory alloy spinules to interlock with soft, dynamic tissues without motors.
• In mid-2025 animal trials demonstrated sustained release of the HIV antiviral cabotegravir over one week from the device adhered to the stomach lining.
• A version incorporating microneedle-style spinules successfully delivered luciferase-encoding RNA into gastrointestinal and oral tissues in vivo.
• By integrating a temperature sensor, MUSAS adhered to swimming fish and provided accurate, high-speed water temperature readings for environmental monitoring.
• Following peer-reviewed publication, the team is exploring next-generation applications including vaccine delivery and implantable electrical stimulation devices.