Overview
- Danish authorities have alerted regulators abroad, and the UK's HFEA says British patients treated in Denmark have been informed.
- The donor’s sperm was supplied to 67 clinics in 14 countries over roughly 17 years.
- Genetic findings indicate the donor is mosaic for a TP53 variant, with up to about 20% of his sperm carrying the Li‑Fraumeni–causing mutation.
- Some donor‑conceived children have died of cancer, and those who inherited the variant face an estimated 90% lifetime risk.
- Belgium’s six‑family cap was exceeded as 38 women conceived 53 children with this donor, and the European Sperm Bank says it is in dialogue with authorities in Denmark and Belgium.