Overview
- Tohoku University scientists report in Neuroscience Research that rats near their tired phase formed longer‑lasting neural changes despite weaker immediate responses.
- Genetically altered rats received precise blue‑light stimulation in the visual cortex, and long‑term potentiation emerged only just before sunrise.
- Adenosine appeared to mediate the effect, as blocking A1 receptors with the drug DPCPX enhanced responses before sunrise but not before sunset.
- Because rats are nocturnal, the fatigued window maps to humans’ late evening, hinting that brief review before sleep could aid retention without sacrificing rest.
- The work focuses on one brain area in animals, so broader learning effects and human relevance require controlled studies before any recommendations.