Rams–49ers Rematch Shapes Up as Week 10’s Highest-Projected Shootout

Oddsmakers expect a shootout with San Francisco a rare home underdog, a reflection of defensive injuries plus Los Angeles’ surge.

Overview

FanDuel lists the 49ers as 3.5-point underdogs at Levi’s Stadium with a 50.5 total, the week’s highest projection.
The Rams have won three straight since the Week 5 loss, allowing a combined 20 points and ranking second in both third-down and red-zone defense.
Matthew Stafford leads the NFL in touchdown passes with 21 in eight games and in passing yards per game, fueling MVP talk.
San Francisco is 6-3 despite season-ending losses to Nick Bosa and Fred Warner, riding Mac Jones’ 5-2 run as a starter and Christian McCaffrey’s league-leading touches and scrimmage yards.
The rematch follows the 49ers’ 26-23 overtime win in Week 5, with Los Angeles entering Sunday holding a narrow lead in the NFC West.