Overview
- FanDuel lists the 49ers as 3.5-point underdogs with a 50.5 over/under, the highest projected total of Week 10.
- The matchup features the 6-2 Rams against the 6-3 49ers, with divisional and conference tiebreakers at stake if Los Angeles drops another head-to-head.
- The Rams have scored 35 and 34 in two of their last three games and have allowed just 20 total points across three straight wins, ranking second in third-down and red-zone defense.
- San Francisco continues without All-Pros Fred Warner and Nick Bosa, elevating Tatum Bethune at linebacker as the offense leans on a tailored plan for Mac Jones, who is 5-2 as a starter (10 TDs, 5 INTs).
- Matthew Stafford leads the NFL in touchdown passes and passing yards per game, while Christian McCaffrey leads the league in touches and yards from scrimmage.