Overview
- Kickoff is scheduled for Sunday, Nov. 9 at 3:25 p.m. CT at Levi's Stadium with live coverage on Fox Sports and DAZN/NFL Game Pass.
- The matchup carries direct NFC West implications, with reporting indicating a Rams win could move them into first place, while a loss could drop them to third.
- San Francisco will open with Mac Jones under center after the team confirmed him as the starter, and Brock Purdy will be in uniform.
- Los Angeles leans on a rejuvenated Puka Nacua alongside Matthew Stafford after signs he has returned to early-season form following injury.
- Pre‑game betting lines list the Rams as favorites, with odds cited at Rams −250 and 49ers +210 on caliente.mx.