Overview
- Los Angeles (6-2) is a roughly 5-point favorite at Levi’s Stadium against San Francisco (6-3) in a Week 10 rematch of the 49ers’ 26-23 overtime win on Oct. 2.
- Mac Jones will make his sixth straight start for the 49ers, while Brock Purdy practiced on a limited basis, is listed as questionable, and worked scout-team reps to mimic Matthew Stafford.
- Stafford leads the NFL with 21 touchdown passes and posted 389 yards and three TDs in the first meeting, facing a 49ers defense low on takeaways and struggling to generate pressure.
- With multiple defensive starters out, San Francisco is leaning heavily on Christian McCaffrey, who leads the league in touches and ranks among the NFL’s leaders in rushing and receiving production.
- Elsewhere, Detroit visits Washington with players acknowledging the playoff loss as motivation but prioritizing ending their current skid, and SportsLine AI rates the Bills as an A+ money-line pick with an average 36-22 projection over Miami.