Overview
- San Francisco (3-1) visits Los Angeles (3-1) at SoFi Stadium in the Week 5 opener on Thursday Night Football.
- USA TODAY's expert panel largely backs the Rams against the spread at -5.5, with only limited dissent.
- ESPN Analytics' Matchup Predictor gives Los Angeles a 57.2% chance to win, compared with 42.5% for San Francisco.
- A short week and multiple 49ers injuries leave quarterback Brock Purdy's availability unresolved, which could shift late odds and picks.
- Coverage highlights live odds and injury updates heading into the Prime Video broadcast, with full Week 5 predictions through Monday's Chiefs at Jaguars finale.