Overview

• Kickoff is 8:15 p.m. ET at SoFi Stadium, with national streaming on Amazon Prime Video and local TV only in the Los Angeles and San Francisco markets.
• The 49ers’ inactives include QB Brock Purdy, WRs Jauan Jennings and Ricky Pearsall, and TE George Kittle, thinning San Francisco’s pass-catching group.
• Both teams entered 3-1, but the spread shifted from about Rams -3.5 early to roughly -8.5 after San Francisco finalized its inactives.
• Mac Jones starts for San Francisco, while Matthew Stafford leads Los Angeles with Puka Nacua in form after a 170-yard, 1-TD performance in Week 4.
• Sportsbooks rolled out TNF promos and player props, with Kyren Williams and Christian McCaffrey featured prominently in anytime-touchdown markets.