Overview
- The Buffalo Bills travel to SoFi Stadium to face the Los Angeles Rams on Monday, Oct. 12, 2026, with kickoff at 8:15 p.m. ET and live coverage on ABC/ESPN and major streaming services.
- Rams coach Sean McVay confirmed Aaron Donald is active for the game after back soreness kept him out last week, giving Los Angeles a significant boost on the defensive line.
- Buffalo will be short-handed for the trip with DJ Moore inactive, Joshua Palmer ruled out, and defensive tackle Ed Oliver out with a knee injury, changes that reduce Josh Allen’s usual receiving and interior pass-rush support.
- Sportsbooks list the Rams as roughly 3.5-point favorites with an over/under around 54.5, and public money and predictive models moved the line toward Los Angeles in the lead-up to kickoff.
- The matchup is widely viewed as a potential Super Bowl preview because it pairs the last two NFL MVPs and rekindles memories of their 44-42 2024 shootout, making play-calling, turnovers and depth the key factors to watch.