Overview

• Kickoff is set for 8:15 p.m. ET at SoFi Stadium in Inglewood, Calif., on Thursday Night Football.
• Both teams enter at 3-1, keeping pace atop the NFC West following the Rams’ Week 4 win and the 49ers’ loss.
• San Francisco rules out George Kittle (hamstring) and Brandon Aiyuk (knee) while Brock Purdy (toe) is listed as questionable after a setback.
• DraftKings lists Los Angeles -5.5 with a total of 47 points and money line odds of Rams -257 and 49ers +208.
• SportsLine’s projection model leans Over with 48 total points, and DFS guidance spotlights Christian McCaffrey and Puka Nacua as top plays.