Overview

• Kickoff is Thursday, Oct. 2 at 8:15 p.m. ET on Prime Video from SoFi Stadium, with Al Michaels, Kirk Herbstreit and Kaylee Hartung on the call.
• Sportsbooks list Los Angeles as a modest favorite, with lines ranging from Rams -3 to -4.5 and totals around 47–47.5 depending on the book.
• The 49ers have injury questions at wide receiver with Ricky Pearsall (knee) and Jauan Jennings (ribs) uncertain, and tight end George Kittle remains on injured reserve.
• Tickets remain available, starting at about $199, with lower-level seats beginning around $462 as of publication.
• For Week 6, the NFL moved Buccaneers–49ers to 4:25 p.m. ET and shifted Patriots–Saints to 1 p.m. ET, with both games airing on CBS.