Overview
- The Bills will play the Los Angeles Rams at SoFi Stadium with kickoff set for 8:15 p.m. ET on Monday, Oct. 12, and the game will air nationally on ESPN/ABC with streaming on NFL+ and Fubo.
- Rams coach Sean McVay confirmed Aaron Donald, tight end Colby Parkinson and cornerback Jaylen Watson are cleared to play, restoring key pieces to Los Angeles’s defense and red‑zone offense.
- Buffalo will be notably shorthanded after losing defensive tackle Ed Oliver (knee) for the game and ruling receiver Joshua Palmer out, with DJ Moore listed as questionable, a set of absences that changes matchup plans.
- Bookmakers opened the Rams as roughly 3 to 3.5‑point favorites with a high total near 54.5 points, and analysts and betting experts remain split on which side to back.
- The matchup matters beyond one night because the Rams entered the season with high expectations but uneven play, while Buffalo’s top offense must contend with a defense that ranks poorly in advanced metrics and now faces key personnel gaps.