Overview

• Both teams enter at 3-1, and the winner is guaranteed at least a share of first place in the NFC West with a chance at sole lead depending on the Seahawks’ result.
• Brock Purdy is out and San Francisco is missing pass-catchers Ricky Pearsall, Jauan Jennings and George Kittle, putting more on Christian McCaffrey’s workload.
• Betting markets heavily back Los Angeles at home, with Rams -440 on the money line, a -8.5 spread and a total around 45.5.
• Aggregated expert picks from USA Today, ESPN and CBS Sports overwhelmingly select the Rams, with only one prediction siding with the 49ers.
• Los Angeles brings a top-five offense led by NFL receiving leader Puka Nacua, while recent meetings in L.A. have been high scoring and the Rams have won the last three in the series.