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32m ago

Rams Favored Over 49ers for Thursday Night at SoFi

Early odds plus model forecasts lean toward Los Angeles.

Will Puka Nacua and the Los Angeles Rams beat the San Francisco 49ers on Thursday Night Football? NFL Week 5 predictions, picks, odds preview the game on Oct. 2, 2025.
Who is favored in the Buffalo Bills vs New England Patriots game on Sunday Night Football? NFL Week 5 odds for betting on every game on the NFL Week 5 schedule this week.
Indianapolis Colts v Los Angeles Rams
The Kansas City Chiefs and Jacksonville Jaguars face off in a key game on the NFL Week 5 schedule this week on Monday Night Football.

Overview

  • The NFC West matchup kicks off Thursday, Oct. 2 at 8:15 p.m. ET at SoFi Stadium and streams on Prime Video.
  • Opening lines show Los Angeles as a small favorite, ranging from -3 at DraftKings to -3.5 at BetMGM and -4.5 at ESPN BET, with totals around 47–47.5.
  • Moneylines vary by book, with recent listings around Rams -180 to -225 and 49ers +150 to +190.
  • Both teams enter 3-1 after Week 4, with the Rams topping the Colts and the 49ers taking their first loss to the Jaguars.
  • Tickets are available on major resale sites starting near $199, with lower-level seats around $462, and several models give the Rams a slight edge as reports cite a season-ending Bosa injury for San Francisco as a market factor.