Overview

• Kickoff is Sunday at 1 p.m. EDT on CBS, with BetMGM listing Los Angeles as a 5.5-point favorite.
• Rookie No. 1 pick Cam Ward makes his home debut after a poised but modest opener (12-of-28, 112 yards, six sacks, no turnovers).
• Titans starting RT JC Latham ruled himself out with a hip strain and veteran Olisaemeka Udoh is the likely replacement; DT T’Vondre Sweat was ruled out Friday with an ankle injury.
• Rams guards Kevin Dotson and Steve Avila are dealing with ankle injuries described as week-to-week, with late-week reports indicating Avila is doubtful and Dotson has no game designation; TE Colby Parkinson is doubtful with a shoulder issue.
• Los Angeles leans on a defense that held Houston to nine points and on WR Puka Nacua (10 catches, 130 yards), while expert picks and betting markets largely back the Rams despite Tennessee’s turnover-hunting defense and Jeffery Simmons’ interior matchup.