Overview

• Kickoff is Sunday, Sept. 28 at 4:05 p.m. ET in Inglewood, with Indianapolis at 3-0 and Los Angeles at 2-1.
• The Rams’ initial Week 4 report listed five limited participants, including Steve Avila (ankle) and Braden Fiske (oblique), with some veteran soreness noted after Week 3.
• Indianapolis monitored multiple absences in practice, including DeForest Buckner, Matt Goncalves, Kenny Moore II and Alec Pierce.
• Sportsbooks list Los Angeles by about 3.5 points, and a multi-outlet expert picks roundup largely backs the Rams.
• Key matchups feature rushing leader Jonathan Taylor versus the Rams’ run defense, Los Angeles’ NFL co-leading pass rush against a Colts line that has allowed two sacks, and a red-zone barometer after L.A.’s struggles and Indy’s perfect TD rate allowed on six trips.