Overview

• A study published in Radiology identifies six breast parenchymal texture phenotypes associated with increased invasive breast cancer risk.
• Researchers analyzed mammograms from over 30,000 women, extracting 390 imaging features condensed into six distinct phenotypes.
• The phenotypes were validated in an independent cohort of more than 3,500 women, showing stronger risk associations in Black women compared to white women.
• These imaging biomarkers could predict false-negative mammograms and interval cancers, offering insights for tailored screening protocols.
• Future research will expand to larger U.S. populations, 3D mammography, and integration with genetic and lifestyle factors to refine risk assessment.