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Quitting Smoking in Midlife or Later Tied to Slower Cognitive Decline, Large UCL Study Finds

Researchers say the observational findings warrant stronger quit support for older smokers.

Overview

  • Across six years after cessation, memory decline slowed by about 20% and verbal fluency decline roughly halved compared with continuing smokers.
  • The analysis followed 9,436 adults aged 40+ in 12 countries, matching more than 4,700 quitters to equal continuing smokers with similar pre-quit trajectories.
  • The two groups showed comparable decline in the six years before some quit, then their cognitive paths diverged after quitting.
  • Authors and independent experts stress the study cannot prove causation and note potential confounders such as socioeconomic background and alcohol use.
  • Findings align with proposed mechanisms involving vascular injury, inflammation and oxidative stress, and add policy impetus to invest in cessation services as UK adult smoking prevalence stands at about 11.9%.