Quercetin Identified as Likely Cause of Red Wine Headaches

University of California, Davis, scientists plan clinical trial to test theory, with susceptibility varying among individuals.

Scientists at the University of California, Davis, have identified quercetin, a flavonol found in grapes, as the likely cause of red wine headaches.
Quercetin, when metabolized with alcohol, inhibits an enzyme called ALDH2, which the body uses to break down alcohol, leading to a buildup of acetaldehyde, a toxic chemical that can cause headaches, facial flushing, and nausea.
Quercetin levels in red wine can vary greatly, influenced by factors such as sunlight exposure of the grapes and the wine-making process.
The researchers are planning a Phase 3 clinical trial to test their theory on volunteers.
It is still unclear why some people are more susceptible to red wine headaches than others.