Overview
- San Francisco moved to 11–4 on Monday night, with Brock Purdy completing 25 of 34 passes for 295 yards and five touchdowns in a career-best outing.
- Christian McCaffrey rushed for 117 yards to eclipse 1,000 on the season and added two receiving touchdowns in a balanced 49ers attack.
- Key momentum swings included a first-quarter kickoff fumble forced by Ji’Ayir Brown and a 74-yard pick-six by linebacker Dee Winters late in the fourth quarter.
- Indianapolis fell to 8–7 with a fifth straight loss despite Philip Rivers going 23-of-35 for 277 yards with two touchdowns and one interception.
- The Colts’ defeat clinched playoff berths for the Buffalo Bills, Jacksonville Jaguars and Los Angeles Chargers with two weeks remaining.