Overview

• Kickoff is 8:15 p.m. ET at SoFi Stadium, with national coverage streaming exclusively on Amazon Prime Video and local TV only in the San Francisco and Los Angeles markets.
• Brock Purdy is officially out with a toe injury, Mac Jones starts for the 49ers, and wide receivers Ricky Pearsall and Jauan Jennings were also ruled out.
• Both teams enter at 3-1, and the Rams are coming off a 27-20 win over the Colts in which Matthew Stafford threw for 375 yards and three touchdowns.
• Sportsbooks list San Francisco as roughly an 8.5-point underdog, with Kyren Williams (-185) and Christian McCaffrey (as low as -120) leading the anytime touchdown odds.
• DFS and prop guidance spotlights Puka Nacua’s league-leading 29 receptions, with major sportsbooks promoting TNF-specific bonuses and offers for the matchup.