Overview

• Kickoff is 4:25 p.m. ET at Raymond James Stadium on CBS, with streaming on Paramount+.
• San Francisco ruled out Brock Purdy (toe) and is expected to start Mac Jones, who played through knee and oblique issues in a 342-yard, two-touchdown outing last week.
• The 49ers activated safety Malik Mustapha from reserve/PUP and elevated defensive lineman Trevis Gipson in final roster moves before Week 6.
• The Buccaneers will be without wide receiver Mike Evans and running back Bucky Irving, as Baker Mayfield continues to lead a productive passing attack with rookie Emeka Egbuka.
• Sportsbooks list Tampa Bay around -3 with a total near 47.5 and a money line near -161, as both clubs enter at 4-1.