Overview
- Brock Purdy was listed inactive with a toe injury, and Mac Jones made his fourth straight start despite knee and oblique issues and limited practices.
- NFL Network's Tom Pelissero reported Jones can earn a $400,000 incentive by leading San Francisco to a fourth win in his starts.
- Safety Malik Mustapha was activated from the PUP list and is active for his season debut as the club adjusts its defensive backfield.
- Ji'Ayir Brown is expected to start alongside rookie Marques Sigle at safety with Jason Pinnock's role reduced, per NBC Sports Bay Area.
- Jauan Jennings was active after ankle and rib injuries and had a first‑half sideline confrontation with coach Kyle Shanahan, while Jones threw an early interception and Adrian Martinez served as the No. 2 quarterback.