Overview
- Brock Purdy enters the matchup with the league’s top passer rating, one of the highest EPA per dropback marks in recent history, 11 touchdown passes and no sacks through four games.
- The Seahawks defense ranks among the NFL’s stingiest, allowing the fewest yards per play and the fewest total yards per game while conceding very few explosive plays.
- San Francisco’s recent struggles versus Mike Macdonald’s unit are stark: the 49ers were outscored 54-9 in the two decisive losses that ended last season and failed to reach the end zone on 19 offensive possessions.
- Seattle wins with its front four on early downs, producing a roughly 44% early‑down pressure rate without heavy blitzing, with Uchenna Nwosu, DeMarcus Lawrence and Leonard Williams as primary disruptors.
- The matchup shifts focus to protection and pocket play as 49ers left tackle Trent Williams and the offensive line must limit early‑down pressure to keep drives going and protect San Francisco’s divisional and playoff outlook.