Overview
- The EADV 2025 presentation detailed a TriNetX retrospective analysis spanning 15 years that included 22,901 patients older than 55 with psoriasis and three propensity-matched control cohorts.
- Over a decade of follow-up, the psoriasis group showed a 56% higher incidence of age-related macular degeneration versus major depressive disorder controls and 21% higher versus melanocytic nevi controls after excluding prior cases.
- Risk rose for both subtypes, with exudative (wet) AMD up 40% and non-exudative (dry) AMD up 13% compared with the major depressive disorder cohort.
- Patients receiving biologic therapies had a 27% lower incidence of new AMD diagnoses than biologic-naïve peers treated only with topical corticosteroids.
- Researchers cited shared lipid dysregulation as a plausible link, cautioned that the observational design limits causal conclusions, and advised standard eye exams while further imaging-based work proceeds.