Overview

• Psilocybin preserved telomere length and extended cellular lifespan by more than 50% in human lung and skin cells.
• In aged mice, survival rates improved by roughly 30% to 80% depending on dosing protocols, and treated animals displayed hair regrowth, fewer white hairs and improved fur quality.
• Mechanistic analyses revealed that psilocybin treatment upregulated SIRT1, downregulated GADD45a and reduced oxidative stress to mitigate cellular senescence.
• The study’s authors caution that optimal dosing schedules, comprehensive safety profiling and confirmation of causal anti-aging effects in humans remain outstanding.
• Research teams at Emory University and Baylor College of Medicine are designing early human studies to refine dosing protocols and monitor potential adverse effects.