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Prue Leith Says Two-Month Mounjaro Trial Brought Side Effects but No Weight Loss

Her account underscores the unpredictable results of GLP-1 weight-loss drugs.

Overview

  • Leith, 85, said she used Mounjaro for two months, lost her appetite and felt persistently tired, yet her weight did not change.
  • She stopped the weekly injections, calling the experience terrible and the medication expensive.
  • Her husband, John Playfair, had a starkly different outcome, losing about two stone (around 28 pounds) on the same drug.
  • Leith has voiced skepticism about relying on injectable jabs long term, arguing that ongoing use is the wrong solution.
  • Medical guidance cited in the coverage notes Mounjaro (tirzepatide) treats type 2 diabetes and can promote weight loss by reducing appetite and slowing digestion, with common side effects including nausea and diarrhea.