Overview

• Subtle shifts in speech speed, sleep patterns, personality traits, financial management, smell accuracy serve as early Alzheimer’s signals before memory loss
• Slower speech rhythms, extended pauses alongside tau pathology precede overt cognitive decline
• The Global Neurodegeneration Proteomics Consortium released an open-access archive with over 300 million protein analyses from 40,000 samples revealing APOE4’s immune-modulatory role
• A UCLA Health eBioMedicine analysis identifies four disease pathways—mental health, encephalopathy, mild cognitive impairment, vascular disease—to improve early detection
• Integrating these multimodal markers with proteomic profiles enables precise risk stratification for targeted preclinical interventions