Overview

• The Cell study delivers the first comprehensive proteomic aging map across 11 human organs.
• Significant proteomic shifts in the aorta and adrenal gland begin around age 30, suggesting early endocrine triggers.
• Most tissues exhibit a pronounced cascade of differentially expressed proteins by age 50, marking accelerated aging.
• Aging blood vessels secrete factors like GAS6 that broadcast signals capable of accelerating decline in other organs.
• Identifying organ-specific aging proteins lays the groundwork for targeted interventions to slow systemic deterioration and cut chronic-disease risk.