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Protein Plaques Can Form in Early Adulthood, but Alzheimer’s at 22 Remains Exceptionally Rare

Clinicians stress early-onset Alzheimer’s generally arises only from specific gene mutations with new study indicating preclinical beta-amyloid accumulation may precede symptoms by decades

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What is Early-Onset Alzheimer's Disease That Saiyaara Showcases, Can You Get the Symptoms in Your 20s

Overview

  • The Bollywood film Saiyaara depicts a 22-year-old battling Alzheimer’s, a scenario neurologists say departs from established age norms.
  • Experts emphasize Alzheimer’s rarely manifests before age 40 and predominantly affects individuals in their forties, fifties or over 65.
  • Inherited gene mutations and conditions such as Down’s syndrome underlie the small number of early-onset cases occurring under age 40.
  • Younger patients often show atypical symptoms—headaches, behavioural shifts and gait disturbances—leading to misdiagnoses and delayed cognitive testing and imaging.
  • A Neurology study reveals beta-amyloid plaques may begin accumulating years before clinical signs, underscoring the need for biomarker research and earlier detection