Overview
- A University of Nottingham–led team reports in Nature Communications that a fluoride-free, protein-based gel rebuilt enamel-like tissue on demineralised human teeth in ex vivo experiments.
- The gel acts as a scaffold for epitaxial crystal growth using calcium and phosphate from saliva, forming an integrated layer up to about 10 micrometres thick within roughly a week.
- Electron microscopy documented aligned crystal regrowth, and mechanical tests simulating brushing, chewing, and acidic exposure showed behavior comparable to healthy enamel.
- The researchers have launched Mintech-Bio and plan first-in-human clinical trials in early 2026, with a first product hoped for toward late 2026.
- Dentists could apply the gel in minutes in a manner similar to fluoride varnishes, and the approach may also build an enamel-like coating over exposed dentin to address sensitivity or support restorations.