Overview

• Prince Frederik passed away on March 1 in Paris, a day after Rare Disease Day, from POLG mitochondrial disease, a rare genetic disorder affecting the body's energy production.
• Frederik founded the POLG Foundation in 2022 to advance research and support for those suffering from mitochondrial diseases, raising over $3.6 million for research projects.
• The disease, caused by mutations in the POLG gene, leads to progressive organ dysfunction and failure, with symptoms ranging from muscle weakness to epilepsy and liver failure.
• Frederik's family described him as a resilient advocate who faced his challenges with humor and grace, leaving a legacy of hope and compassion through his foundation's work.
• His father, Prince Robert, shared an emotional tribute, recounting Frederik's final moments and his lasting impact on the global scientific and patient communities.