Prince Frederik of Luxembourg Dies at 22 from Rare Genetic Disease

The young royal, diagnosed with POLG mitochondrial disease at 14, dedicated his life to raising awareness and funding research for the incurable condition.

Prince Frederik passed away on March 1 in Paris, a day after Rare Disease Day, from POLG mitochondrial disease, a rare genetic disorder affecting the body's energy production.
Frederik founded the POLG Foundation in 2022 to advance research and support for those suffering from mitochondrial diseases, raising over $3.6 million for research projects.
The disease, caused by mutations in the POLG gene, leads to progressive organ dysfunction and failure, with symptoms ranging from muscle weakness to epilepsy and liver failure.
Frederik's family described him as a resilient advocate who faced his challenges with humor and grace, leaving a legacy of hope and compassion through his foundation's work.
His father, Prince Robert, shared an emotional tribute, recounting Frederik's final moments and his lasting impact on the global scientific and patient communities.