Overview

• Researchers at Barcelona’s Hospital de Sant Pau found that the APOE4 genetic variant impairs neuronal uptake of cholesterol, as detailed in the August 6 Journal of Lipid Research publication.
• Harvard Medical School scientists showed that amyloid plaques sequester lithium in the brain, leading to accelerated plaque formation and cognitive decline in mouse models.
• A lithium orotate formulation evades plaque sequestration, restores natural brain lithium levels and reverses memory loss and neuropathology in Alzheimer’s mice without traditional lithium side effects.
• The Global Neurodegeneration Proteomics Consortium’s open-access archive and recent Alzheimer’s Association grants to CONICET labs are guiding exploration of these molecular targets.
• Experts emphasize the preliminary nature of these findings and call for controlled human trials to evaluate safety, dosing and therapeutic impact.