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Potent Nitazene Opioids Surge in U.S. Supply, Linked to Texas Overdose Deaths

Limited toxicology screening coupled with reduced naloxone effectiveness has driven calls for broader monitoring measures.

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Overview

  • Two Texas men, aged 21 and 22, died this year after ingesting counterfeit Xanax and Percocet pills laced with nitazene analogues up to 25 times more lethal than fentanyl.
  • U.S. Customs and DEA officials report intercepting nitazene shipments from clandestine Chinese chemical suppliers multiple times a week at ports such as JFK.
  • Harris County medical examiners do not include nitazenes in routine toxicology panels and only test for them when other causes of death remain unexplained.
  • Emergency responders have administered multiple naloxone doses to reverse nitazene overdoses, highlighting gaps in the standard overdose treatment protocol.
  • Families of the victims and health experts are urging expanded drug checking, wastewater surveillance and rapid public-health alerts to stem further fatalities.