Overview
- Individuals with higher two-hour postprandial glucose had a 69% greater risk of Alzheimer’s disease.
- The association was not explained by overall brain volume or white-matter damage, pointing to subtler mechanisms.
- Researchers examined fasting glucose, insulin, and two-hour post-meal glucose, with postprandial levels emerging as the key signal.
- The analysis used genetic data from over 350,000 adults aged 40–69 in the UK Biobank to strengthen causal inference.
- The authors urge replication in diverse populations before informing prevention or clinical guidance, noting potential relevance for managing after-meal glucose.