Overview

• Developed from genetic data on over five million people and published in Nature Medicine, the score is now publicly available as a research prototype
• It accounts for 17.6% of variation in adult BMI, doubling the predictive power of previous genetic tests
• The score identifies children at high obesity risk before age five, creating opportunities for early prevention
• It forecasts response to intensive lifestyle programs, showing that higher-risk individuals lose more weight initially but regain more over time
• Researchers are working to enhance accuracy in non-European ancestry groups and integrate the score into clinical and public health frameworks